Sildenafil citrate was originally developed in 1991 as a treatment for angina, or chest pain. The drug, marketed under the name zenegra, received FDA approval as a treatment for erectile dysfunction in March 1998, and since that time it has been prescribed for more then 20 million men worldwide. It was the first oral medication approved for ED treatment. Zenegra is a vasodilator, a drug that has the effect of dilating the blood vessels. It works by improving blood circulation to the penis, and by enhancing the effects of nitric oxide, the agent that relaxes the smooth muscle of the penis and regulates blood vessels during sexual stimulation, allowing the penis to become engorged and achieve an erection. The average recommended dose of zenegra is 50 mg. It comes in doses of 25 mg., 50 mg., and 100 mg to. The medication is taken approximately one hour before sexual activity is planned, and may remain effective for up to four hours. One drawback is that to be effective, it should be taken on an empty stomach. Also, high-fat foods can interfere with the absorption of zenegra. Zenegra does not increase sexual desire. Sexual stimulation and arousal are required for it to be effective. Many insurance plans cover the cost of zenegra, provided it is prescribed to treat erectile dysfunction. The pills cost approximately $10 each, and insurers may limit coverage to a specific number of pills each month. The primary drawback to zenegra, which works about an hour after it is taken, it that the FDA cautions men with heart disease or low blood pressure to be thoroughly examined by a physician before obtaining a prescription. At least 130 men have died while taking zenegra. However, the FDA said the men—most over the age of 64—died of heart attack or stroke due to health problems exaggerated by sexual activity, not the drug itself. Join 20,000+ subscribers and receive the latest health news each fortnight! Spotlight on Stone Management 703. Moemen MN, Hamed HA, Kamel, II et al: Clinical and sonographic assessment of the side effects of intracavernous injection of vasoactive substances. Int J Impot Res 2004; 16: 143.   Cialis (Tadalafil) Corporate Support Catalog Men’s Health Cavernosal disorders (Peyronie's disease[4]) Gene Expression Omnibus (GEO) Datasets What Should You Tell Your Doctor About Symptoms? Does Masturbation Affect Sexual Stamina? Conclusion When talking to your doctor, be as open and honest about your symptoms as possible. Tell your healthcare provider how often you have symptoms and how long you’ve had them. The risks of acupuncture are low if provided by a licensed acupuncturist. Acupuncture shows promise for treating ED, but more studies are needed. human sexual behaviour PMID: 329. Fonseca V, Seftel A, Denne J et al: Impact of diabetes mellitus on the severity of erectile dysfunction and response to treatment: analysis of data from tadalafil clinical trials. Diabetologia 2004; 47: 1914.   Rosen RC, Jackson G, Kostis JB. Erectile dysfunction and cardiac disease: Recommendations of the Second Princeton Conference. Curr Urol Rep. 2006; 7(6): 490-6.

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Copyright/Permissions Symptoms and self help 333. Grover-Paez F, Villegas Rivera G and Guillen Ortiz R: Sildenafil citrate diminishes microalbuminuria and the percentage of A1c in male patients with type 2 diabetes. Diabetes Res Clin Pract 2007; 78: 136.   553. Aversa A, Isidori AM, Spera G et al: Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction. Clin Endocrinol (Oxf) 2003; 58: 632.   232. Morgentaler A, Barada J, Niederberger C et al: Efficacy and safety of tadalafil across ethnic groups and various risk factors in men with erectile dysfunction: use of a novel noninferiority study design. J Sex Med 2006; 3: 492.   Further reading and references latest headlines Reviewed by Alana Biggers, MD, MPH Your sperm health Sex therapists should be a member of the: Excellent 9.3/10 804. Fein RL: GFS Mark II inflatable penile prosthesis: four-year clinical study. Urology 1994; 43: 209.   Drugs in development Credit: Neil Gould | Stock Xchng Submit February 22, 2014 Many medications can cause or contribute to erectile dysfunction, including certain blood pressure drugs, antidepressants, and tranquilizers. Men with erectile dysfunction should talk with their doctor if they suspect a prescription or over-the-counter drug may be causing erectile problems. Avoid drinking too much alcohol (no more than two drinks a day); Learn more about Erectile Dysfunction 5 scary things that happen to your penis when you age Dizziness Patients & Visitors Dr Joe: Stress Management 8. Prostate Specific Antigen (PSA) Levels Enter search terms Cell Lines THESAURUS Help the couple define a plan for rebuilding their sexual and emotional relationship based on their own particular physical and emotional circumstances. Omudhome Ogbru, PharmD Edit links Losing extra weight 211 Tadalafil shares the common side effects of the PDE5 inhibitors, however, due to its effect on PDE11, another phosphodiesterase located in muscle, tadalafil has been associated with muscle aches. Back pain and muscle aches occur in less than 7% of men taking tadalafil and in most patients will go away without treatment within 48 hours. When treatment was necessary, acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil) or naproxen (Aleve) were effective. Rarely do the muscle aches and back pain cause men to stop using tadalafil. Circulatory problems: An erection occurs when the penis fills with blood and a valve at the base of the penis traps it. Diabetes, high blood pressure, cholesterol, clots, and atherosclerosis (hardening of the arteries) can all interfere with this process. Such circulatory problems are the number one cause of erectile dysfunction. Frequently, erectile dysfunction is the first noticeable symptom of cardiovascular disease. 982. Weidner W, Weiske WH, Rudnick J et al: Venous surgery in veno-occlusive dysfunction: long-time results after deep dorsal vein resection. Urol Int 1992; 49: 24.   Medication. 728. Soderdahl DW, Thrasher JB and Hansberry KL: Intracavernosal drug-induced erection therapy versus external vacuum devices in the treatment of erectile dysfunction. Br J Urol 1997; 79: 952.   Erectile Dysfunction Home 7. Lifestyle Factors What is Erectile Dysfunction? Erectile dysfunction is commonly used in a lot of modern day sexual jokes or innuendos. However, it is a little-known fact... ed|Great Solutions Available Here ed|Great Tips & Methods Available Here ed|Great Tips Available Here
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